Translational Health and Bioscience at the Biomarker Research and Individualized Medicine Center

The University of Toledo


University of Toledo


The University of Toledo Center of Excellence in Translational Health and Bioscience at the Biomarker Research and Individualized Medicine (BRIM) Center's mission is to improve the human condition through biomedical innovation resulting from effective multidisciplinary and inter-professional excellence in biomedical research and education, with a focus towards biomarker discovery, and distinctive entrepreneurship to bring innovations to the community. The Center's vision is that UT will be a recognized leader in biomedical research with distinction in biomarker discovery and personalized medicine, thereby transforming health and biomedical science. The BRIM Center was established in recognition of the University's remarkable consolidated and focused expertise in the biosciences and biomarkers. The BRIM Center united 12 key contributors and 46 supporting investigators from four UT colleges and from five Featured Academic Services Tracks in clinical science as well as basic science: Cancer Biology & Diagnostics; Cardiovascular & Metabolic Disease; Infection, Immunology & Transplantation; Neuroscience & Neurological Diseases; and Kinetic-Related Sciences & Disorders.

Driving Economic Advancement

The biomarker market is expected to reach $20 billion by 2015. In 2007, the externally benchmarked economic impact of UT College of Medicine (UT-COM) and its academic health care industry in the State of Ohio equaled $5.3 billion. Further, the UT-COM and its core and non-core teaching hospital affiliates accounted for over 57,000 Ohio full-time equivalent positions and $177.6 million in total state tax revenue. Graduates of UT-COM that remain in Ohio to establish medical practices account for an additional economic impact of $65 million annually. UT currently has eleven demonstrated candidate biomarkers discovered by UT investigators, which provide excellent substrate for further validation, development and subsequent commercialization into the Ohio economic base. The BRIM Center is poised to continue to extend the number of bioscience spin-offs from the current eight (four of which are biomarker focused). The BRIM Center will continue to build a robust bioscience cluster and stimulate further economic development, boost programmatic growth of regional biotech/pharmaceutical industry, and create new high-tech job opportunities in Ohio.


  • Core facilities include the Advanced Microscopy & Imaging Core Lab Center, the Electron Microscopy Facility, the Bioinformatics Core Lab Facility, the Flow Cytometry Core, the Laboratory Animal Medicine Core, the Proteomics & Genomics Core and the Jacobson Center for Clinical & Translational Research (JCCTR)
  • JCCTR is uniquely suited to move statewide biomarkers and other bioscience drugs, devices and concepts from the bench to the bedside


  • Recruit nine additional renowned and highly respected biomarker discovery and commercialization experts
  • Create a Biomarker Validation Core Lab Facility equipped with state-of-the-art biobank and 'omics technology and associated technicians and epidemiologists
  • Develop additional biosciences graduate programs in translational research
  • Double the extramural biomarker research funding from $15 million to $30 million per year
  • Quadruple funding in intellectual property protection and technology transfer


  • Biomarker Validation Core in operation
  • Faculty recruitment
  • Funding – NIH, state and private
  • Intellectual Property – invention disclosures, patents, licenses, and spin-offs